Screening history and risk of death from prostate cancer: a nested case–control study within the screening arm of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC)

Kirsi Talala, Stephen Walter, Kimmo Taari, Teuvo L.J. Tammela, Paula Kujala, Anssi Auvinen

Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

7 Lataukset (Pure)

Abstrakti

Purpose: We assessed the risk of death from prostate cancer (PCa) in relation to men’s screening histories, i.e., screening attendance among men who were offered screening. Methods: Men in the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) screening arm were invited to up to three screening rounds with the serum prostate-specific antigen (PSA) test at 4-year intervals during 1996–2007. Case subjects (n = 330) were men who died from PCa. Each case was matched to five controls (n = 1544) among the men who were free of PCa. Screening history was defined as (1) never/ever attended screening prior to the case diagnosis; (2) attended at the first screening round; and (3) recency of screening, calculated as the time from last screening attendance to the date of case diagnosis. The association between screening history and the risk of death from PCa was estimated by odds ratios (OR) with 95% confidence intervals (CI) using conditional logistic regression. Results: Having ever attended screening versus never attended was associated with a reduced risk of PCa death (OR 0.60, 95% CI 0.45–0.81) and a similar association was found for those attended (versus not attended) the first screening round (OR 0.67, 95% CI 0.51–0.87). The effect by time since last screen for the risk of PCa death was significantly lower 2–7 years since last screen. Conclusion: Among men invited to screening, subjects who attended any PSA screening during the previous 19 years had a 40% reduction in PCa mortality compared to non-screened men.

AlkuperäiskieliEnglanti
Sivut695-703
JulkaisuCancer Causes and Control
Vuosikerta35
Varhainen verkossa julkaisun päivämäärä8 jouluk. 2023
DOI - pysyväislinkit
TilaJulkaistu - 2024
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

!!ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Sormenjälki

Sukella tutkimusaiheisiin 'Screening history and risk of death from prostate cancer: a nested case–control study within the screening arm of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC)'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä