Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland

Juuso Jalasto; Paula Kauppi; Ritva Luukkonen; Ari Lindqvist; Arnulf Langhammer; Hannu Kankaanranta; Helena Backman; Eva Rönmark; Anssi Sovijärvi; Päivi Piirilä

doi:10.1080/15412555.2022.2061935

Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland

Juuso Jalasto^*
, Paula Kauppi
, Ritva Luukkonen
, Ari Lindqvist
, Arnulf Langhammer
, Hannu Kankaanranta
, Helena Backman
, Eva Rönmark
, Anssi Sovijärvi
, Päivi Piirilä

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

6 Sitaatiot (Scopus)

24 Lataukset (Pure)

Abstrakti

Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this prospective study was to observe the overall mortality in obstructive pulmonary diseases and how mortality was related to specific causes using postal questionnaire data. This study included data from 6,062 participants in the FinEsS Helsinki Study (1996) linked to mortality data during a 24-year follow-up. According to self-reported physician diagnosed asthma, COPD, or smoking status, the population was divided into five categories: combined asthma and COPD, COPD alone and asthma alone, ever-smokers without asthma or COPD and never-smokers without asthma or COPD (reference group). For the specific causes of death both the underlying and contributing causes of death were used. Participants with asthma and COPD had the highest hazard of mortality 2.4 (95% CI 1.7–3.5). Ever-smokers without asthma or COPD had a 9.5 (3.7–24.2) subhazard ratio (sHR) related to lower respiratory tract disease specific causes. For asthma, COPD and combined, the corresponding figures were 10.8 (3.4–34.1), 25.0 (8.1–77.4), and 56.1 (19.6–160), respectively. Ever-smokers without asthma or COPD sHR 1.7 (95% CI 1.3–2.5), and participants with combined asthma and COPD 3.5 (1.9–6.3) also featured mortality in association with coronary artery disease. Subjects with combined diseases had the highest hazard of overall mortality and combined diseases also showed the highest hazard of mortality associated with lower respiratory tract causes or coronary artery causes. Abbreviations:Cig Cigarette COPD Chronic obstructive pulmonary disease CVD Cardiovascular disease FEV₁ Forced Expiratory Volume in one second FVC Forced Vital Capacity FinEsS Finland, Estonia, and Sweden study on chronic obstructive pulmonary diseases HR Hazard Ratio sHR Subhazard Ratio ICD-10 International Statistical Classifications of Diseases and Related Health Problems (Version 10).

Alkuperäiskieli	Englanti
Sivut	226-235
Sivumäärä	10
Julkaisu	COPD: Journal of Chronic Obstructive Pulmonary Disease
Vuosikerta	19
Numero	1
DOI - pysyväislinkit	https://doi.org/10.1080/15412555.2022.2061935
Tila	Julkaistu - 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. We would like to thank Professor Bo Lundb?ck from G?teborg University for conceptualization and organising of the original FinEsS-study. We would like to thank Professor Tari Haahtela for his input regarding the diagnose and treatment of asthma in Finland. We would also like to thank Statistic Finland and Senior Statistician Airi Pajunen from Statistic Finland for collecting and maintaining causes of death registry and for consulting on the cause of death assignment in Finland. We would also thank the research nurse Kerstin Ahlskog for maintaining the FinEsS-data in the Respiratory Research Unit of the Helsinki University Hospital and for helping to collect the data for mortality analyses. This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: Väinö ja Laina Kiven säätiö; Ida Montinin Säätiö; Hengityssairauksien tutkimussäätiö. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library.

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

SDG 3 – Hyvä terveys ja hyvinvointi

Julkaisufoorumi-taso

Jufo-taso 1

!!ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Pääsy asiakirjaan

10.1080/15412555.2022.2061935Lisenssi: CC BY

15412555.2022Final published version, 1,41 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202206095581Lisenssi: CC BY

Siteeraa tätä

Jalasto, J., Kauppi, P., Luukkonen, R., Lindqvist, A., Langhammer, A., Kankaanranta, H., Backman, H., Rönmark, E., Sovijärvi, A., & Piirilä, P. (2022). Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland. COPD: Journal of Chronic Obstructive Pulmonary Disease, 19(1), 226-235. https://doi.org/10.1080/15412555.2022.2061935

@article{e8adaa986803453689874233eac90d19,

title = "Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland",

abstract = "Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this prospective study was to observe the overall mortality in obstructive pulmonary diseases and how mortality was related to specific causes using postal questionnaire data. This study included data from 6,062 participants in the FinEsS Helsinki Study (1996) linked to mortality data during a 24-year follow-up. According to self-reported physician diagnosed asthma, COPD, or smoking status, the population was divided into five categories: combined asthma and COPD, COPD alone and asthma alone, ever-smokers without asthma or COPD and never-smokers without asthma or COPD (reference group). For the specific causes of death both the underlying and contributing causes of death were used. Participants with asthma and COPD had the highest hazard of mortality 2.4 (95\% CI 1.7–3.5). Ever-smokers without asthma or COPD had a 9.5 (3.7–24.2) subhazard ratio (sHR) related to lower respiratory tract disease specific causes. For asthma, COPD and combined, the corresponding figures were 10.8 (3.4–34.1), 25.0 (8.1–77.4), and 56.1 (19.6–160), respectively. Ever-smokers without asthma or COPD sHR 1.7 (95\% CI 1.3–2.5), and participants with combined asthma and COPD 3.5 (1.9–6.3) also featured mortality in association with coronary artery disease. Subjects with combined diseases had the highest hazard of overall mortality and combined diseases also showed the highest hazard of mortality associated with lower respiratory tract causes or coronary artery causes. Abbreviations:Cig Cigarette COPD Chronic obstructive pulmonary disease CVD Cardiovascular disease FEV1 Forced Expiratory Volume in one second FVC Forced Vital Capacity FinEsS Finland, Estonia, and Sweden study on chronic obstructive pulmonary diseases HR Hazard Ratio sHR Subhazard Ratio ICD-10 International Statistical Classifications of Diseases and Related Health Problems (Version 10).",

keywords = "Asthma, COPD, mortality, prospective study",

author = "Juuso Jalasto and Paula Kauppi and Ritva Luukkonen and Ari Lindqvist and Arnulf Langhammer and Hannu Kankaanranta and Helena Backman and Eva R{\"o}nmark and Anssi Sovij{\"a}rvi and P{\"a}ivi Piiril{\"a}",

note = "Funding Information: This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. We would like to thank Professor Bo Lundb?ck from G?teborg University for conceptualization and organising of the original FinEsS-study. We would like to thank Professor Tari Haahtela for his input regarding the diagnose and treatment of asthma in Finland. We would also like to thank Statistic Finland and Senior Statistician Airi Pajunen from Statistic Finland for collecting and maintaining causes of death registry and for consulting on the cause of death assignment in Finland. We would also thank the research nurse Kerstin Ahlskog for maintaining the FinEsS-data in the Respiratory Research Unit of the Helsinki University Hospital and for helping to collect the data for mortality analyses. This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. Funding Information: This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V{\"a}in{\"o} ja Laina Kiven s{\"a}{\"a}ti{\"o}; Ida Montinin S{\"a}{\"a}ti{\"o}; Hengityssairauksien tutkimuss{\"a}{\"a}ti{\"o}. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2022",

doi = "10.1080/15412555.2022.2061935",

language = "English",

volume = "19",

pages = "226--235",

journal = "COPD: Journal of Chronic Obstructive Pulmonary Disease",

issn = "1541-2555",

publisher = "American School of Classical Studies at Athens",

number = "1",

}

Jalasto, J, Kauppi, P, Luukkonen, R, Lindqvist, A, Langhammer, A, Kankaanranta, H, Backman, H, Rönmark, E, Sovijärvi, A & Piirilä, P 2022, 'Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland', COPD: Journal of Chronic Obstructive Pulmonary Disease, Vuosikerta 19, Nro 1, Sivut 226-235. https://doi.org/10.1080/15412555.2022.2061935

Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland. / Jalasto, Juuso; Kauppi, Paula; Luukkonen, Ritva et al.
julkaisussa: COPD: Journal of Chronic Obstructive Pulmonary Disease, Vuosikerta 19, Nro 1, 2022, s. 226-235.

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland

AU - Jalasto, Juuso

AU - Kauppi, Paula

AU - Luukkonen, Ritva

AU - Lindqvist, Ari

AU - Langhammer, Arnulf

AU - Kankaanranta, Hannu

AU - Backman, Helena

AU - Rönmark, Eva

AU - Sovijärvi, Anssi

AU - Piirilä, Päivi

N1 - Funding Information: This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. We would like to thank Professor Bo Lundb?ck from G?teborg University for conceptualization and organising of the original FinEsS-study. We would like to thank Professor Tari Haahtela for his input regarding the diagnose and treatment of asthma in Finland. We would also like to thank Statistic Finland and Senior Statistician Airi Pajunen from Statistic Finland for collecting and maintaining causes of death registry and for consulting on the cause of death assignment in Finland. We would also thank the research nurse Kerstin Ahlskog for maintaining the FinEsS-data in the Respiratory Research Unit of the Helsinki University Hospital and for helping to collect the data for mortality analyses. This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: V?in? ja Laina Kiven s??ti?; Ida Montinin S??ti?; Hengityssairauksien tutkimuss??ti?. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. Funding Information: This work was supported by The Nordic Council of Ministers: NordForsk Foundation (Nordic EpiLung Study). The corresponding author has received funding from the following non-governmental foundations: Väinö ja Laina Kiven säätiö; Ida Montinin Säätiö; Hengityssairauksien tutkimussäätiö. The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, in writing of the manuscript and in the decision to submit it for publication. The corresponding author had full access to all the data and had final responsibility for the decision to submit for publication. Open access was funded by Helsinki University Library. Publisher Copyright: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2022

Y1 - 2022

N2 - Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this prospective study was to observe the overall mortality in obstructive pulmonary diseases and how mortality was related to specific causes using postal questionnaire data. This study included data from 6,062 participants in the FinEsS Helsinki Study (1996) linked to mortality data during a 24-year follow-up. According to self-reported physician diagnosed asthma, COPD, or smoking status, the population was divided into five categories: combined asthma and COPD, COPD alone and asthma alone, ever-smokers without asthma or COPD and never-smokers without asthma or COPD (reference group). For the specific causes of death both the underlying and contributing causes of death were used. Participants with asthma and COPD had the highest hazard of mortality 2.4 (95% CI 1.7–3.5). Ever-smokers without asthma or COPD had a 9.5 (3.7–24.2) subhazard ratio (sHR) related to lower respiratory tract disease specific causes. For asthma, COPD and combined, the corresponding figures were 10.8 (3.4–34.1), 25.0 (8.1–77.4), and 56.1 (19.6–160), respectively. Ever-smokers without asthma or COPD sHR 1.7 (95% CI 1.3–2.5), and participants with combined asthma and COPD 3.5 (1.9–6.3) also featured mortality in association with coronary artery disease. Subjects with combined diseases had the highest hazard of overall mortality and combined diseases also showed the highest hazard of mortality associated with lower respiratory tract causes or coronary artery causes. Abbreviations:Cig Cigarette COPD Chronic obstructive pulmonary disease CVD Cardiovascular disease FEV1 Forced Expiratory Volume in one second FVC Forced Vital Capacity FinEsS Finland, Estonia, and Sweden study on chronic obstructive pulmonary diseases HR Hazard Ratio sHR Subhazard Ratio ICD-10 International Statistical Classifications of Diseases and Related Health Problems (Version 10).

AB - Asthma and COPD are common chronic obstructive respiratory diseases. COPD is associated with increased mortality, but for asthma the results are varying. Their combination has been less investigated, and the results are contradictory. The aim of this prospective study was to observe the overall mortality in obstructive pulmonary diseases and how mortality was related to specific causes using postal questionnaire data. This study included data from 6,062 participants in the FinEsS Helsinki Study (1996) linked to mortality data during a 24-year follow-up. According to self-reported physician diagnosed asthma, COPD, or smoking status, the population was divided into five categories: combined asthma and COPD, COPD alone and asthma alone, ever-smokers without asthma or COPD and never-smokers without asthma or COPD (reference group). For the specific causes of death both the underlying and contributing causes of death were used. Participants with asthma and COPD had the highest hazard of mortality 2.4 (95% CI 1.7–3.5). Ever-smokers without asthma or COPD had a 9.5 (3.7–24.2) subhazard ratio (sHR) related to lower respiratory tract disease specific causes. For asthma, COPD and combined, the corresponding figures were 10.8 (3.4–34.1), 25.0 (8.1–77.4), and 56.1 (19.6–160), respectively. Ever-smokers without asthma or COPD sHR 1.7 (95% CI 1.3–2.5), and participants with combined asthma and COPD 3.5 (1.9–6.3) also featured mortality in association with coronary artery disease. Subjects with combined diseases had the highest hazard of overall mortality and combined diseases also showed the highest hazard of mortality associated with lower respiratory tract causes or coronary artery causes. Abbreviations:Cig Cigarette COPD Chronic obstructive pulmonary disease CVD Cardiovascular disease FEV1 Forced Expiratory Volume in one second FVC Forced Vital Capacity FinEsS Finland, Estonia, and Sweden study on chronic obstructive pulmonary diseases HR Hazard Ratio sHR Subhazard Ratio ICD-10 International Statistical Classifications of Diseases and Related Health Problems (Version 10).

KW - Asthma

KW - COPD

KW - mortality

KW - prospective study

U2 - 10.1080/15412555.2022.2061935

DO - 10.1080/15412555.2022.2061935

M3 - Article

C2 - 35471091

AN - SCOPUS:85128929253

SN - 1541-2555

VL - 19

SP - 226

EP - 235

JO - COPD: Journal of Chronic Obstructive Pulmonary Disease

JF - COPD: Journal of Chronic Obstructive Pulmonary Disease

IS - 1

ER -

Jalasto J, Kauppi P, Luukkonen R, Lindqvist A, Langhammer A, Kankaanranta H et al. Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2022;19(1):226-235. doi: 10.1080/15412555.2022.2061935

Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone–A Prospective 24-Year Study in the Population of Helsinki, Finland

Abstrakti

Rahoitus

YK:n kestävän kehityksen tavoitteet

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

Pääsy asiakirjaan

Sormenjälki

Siteeraa tätä