Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

Jiyeong Kim, Jukka Kuusela, Katriina Aalto-Setälä, Esa Räsänen

    Tutkimustuotos: KonferenssiartikkeliScientificvertaisarvioitu

    1 Sitaatiot (Scopus)
    5 Lataukset (Pure)

    Abstrakti

    A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.
    AlkuperäiskieliEnglanti
    OtsikkoComputing in Cardiology 2017
    ToimittajatC Pickett, C Corsi, P Laguna, R MacLeod
    Sivut1-4
    Sivumäärä4
    Vuosikerta44
    DOI - pysyväislinkit
    TilaJulkaistu - 2017
    OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa
    TapahtumaCOMPUTING IN CARDIOLOGY CONFERENCE -
    Kesto: 1 tammik. 2017 → …

    Julkaisusarja

    NimiComputing in Cardiology
    ISSN (painettu)2325-8861

    Conference

    ConferenceCOMPUTING IN CARDIOLOGY CONFERENCE
    Ajanjakso1/01/17 → …

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