Spectral changes in spontaneous MEG activity across the lifespan

Carlos Gómez, Jose M. Perez-Macias, Jesús Poza, Alberto Fernández, Roberto Hornero

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

23 Sitaatiot (Scopus)

Abstrakti

OBJECTIVE: The aim of this study is to explore the spectral patterns of spontaneous magnetoencephalography (MEG) activity across the lifespan.

APPROACH: Relative power (RP) in six frequency bands (delta, theta, alpha, beta-1, beta-2 and gamma) was calculated in a sample of 220 healthy subjects with ages ranging from 7 to 84 years.

MAIN RESULTS: A significant RP decrease in low-frequency bands (i.e. delta and theta) and a significant increase in high bands (mainly beta-1 and beta-2) were found from childhood to adolescence. This trend was observed until the sixth decade of life, though only slight changes were found. Additionally, healthy aging was characterized by a power increase in low-frequency bands. Our results show that spectral changes across the lifespan may follow a quadratic relationship in delta, theta, alpha, beta-2 and gamma bands with peak ages being reached around the fifth or sixth decade of life.

SIGNIFICANCE: Our findings provide original insights into the definition of the 'normal' behavior of age-related MEG spectral patterns. Furthermore, our study can be useful for the forthcoming MEG research focused on the description of the abnormalities of different brain diseases in comparison to cognitive decline in normal aging.

AlkuperäiskieliEnglanti
Sivut066006
JulkaisuJournal of Neural Engineering
Vuosikerta10
Numero6
DOI - pysyväislinkit
TilaJulkaistu - jouluk. 2013
Julkaistu ulkoisestiKyllä
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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