Stochastic modeling of inositol-1,4,5-trisphosphate receptors in Purkinje cell spine

Julkaisun otsikon käännös: Stochastic modeling of inositol-1,4,5-trisphosphate receptors in Purkinje cell spine

K. Hituri, P. Achard, S. Wils, M-L. Linne, E. De Schutter

    Tutkimustuotos: KonferenssiartikkeliTieteellinenvertaisarvioitu

    50 Lataukset (Pure)

    Abstrakti

    Transient rises in cytosolic calcium concentration play a crucial role in initiating long-term depression (LTD) of synaptic activity. Calcium release from endoplasmic reticulum is particularly important in LTD. In Purkinje cells, the release is mediated by inositol-1,4,5-trisphosphate (IP₃) receptors (IP₃Rs) that are highly expressed in dendritic spines. The small volume of spine and the small number of molecules involved increase stochasticity in biochemical processes. We studied the effects of stochasticity by comparing stochastic and deterministic simulations for two different IP₃R models. We found a significant difference between the responses when using small initial concentration of calcium or IP₃. Deterministic simulations of IP₃R activation do not produce realistic results under all conditions.
    Julkaisun otsikon käännösStochastic modeling of inositol-1,4,5-trisphosphate receptors in Purkinje cell spine
    AlkuperäiskieliEnglanti
    OtsikkoProceedings of the Fifth International Workshop on Computational Systems Biology, WCSB 2008, Leipzig, Germany, 11-13 June 2008
    ToimittajatM. Ahdesmäki
    Sivut57-60
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa

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