Surface modification of silicate, borosilicate and phosphate bioactive glasses to improve/control protein adsorption: PART I

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

4 Lataukset (Pure)

Abstrakti

Bioactive glasses (BGs) are promising for bone tissue regeneration. BG composition can be tailored, according to the application of interest, and/or functionalized with organic molecules/biomolecules to improve their performances. However, despite the wide knowledge concerning BGs, their interaction with proteins, fundamental for controlling the fate of the implant, has not been deeply investigated yet. Controlling or predicting protein adsorption requires a full understanding of the materials surface physico-chemical properties. In this work, four different BGs (S53P4, B25, SCNB, PhGlass) were surface-modified by four different treatments: 72 h-soaking in TRIS, 72 h soaking in simulated body fluid, APTES grafting and quaternized APTES grafting. The surfaces were then characterized both untreated and after each treatment by contact angle, zeta potential analysis, X-ray photoelectron spectroscopy, Fourier Transform InfraRed–Attenuated Total Reflectance spectroscopy and Scanning Electron Microscopy and Energy Dispersive Spectroscopy. Inductively Coupled Plasma – Optical Emission Spectrometry was then performed to investigate the ion leaching. The aim of this study (Part I) is the physico-chemical characterization of BGs as a function of the implemented treatments, aiming to better understand how the superficial properties are successively affecting protein adsorption. Protein adsorption on untreated and treated BGs will be discussed in a following manuscript (Part II).

AlkuperäiskieliEnglanti
Sivut1261-1275
Sivumäärä15
JulkaisuCeramics International
Vuosikerta49
Numero1
Varhainen verkossa julkaisun päivämäärä24 marrask. 2022
DOI - pysyväislinkit
TilaJulkaistu - 1 tammik. 2023
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

!!ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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