@inproceedings{5627ebcf6815407988ef2992aa18b9cc,
title = "Synchrony between Genetic Repressilators in Sister Cells in Different Temperatures",
abstract = "We used live E. coli containing synthetic genetic oscillators to study how the degree of synchrony between the genetic circuits of sister cells changes with temperature. We found that both the mean and the variability of the degree of synchrony between the fluorescence signals from sister cells are affected by temperature. Also, while most pairs of sister cells were found to be highly synchronous in each condition, the number of asynchronous pairs increased with increasing temperature, which was found to be due to disruptions in the oscillations. Finally we provide evidence that these disruptions tend to affect multiple generations as opposed to individual cells. These findings provide insight in how to design more robust synthetic circuits and in how cell division can affect their dynamics.",
keywords = "repressilator, robustness, synchrony, synthetic biology",
author = "Chandraseelan, {Jerome G.} and Oliveira, {Samuel M.D.} and Antti H{\"a}kkinen and Sofia Startceva and Ribeiro, {Andre S.}",
year = "2015",
language = "English",
series = "Proceedings of the World Academy of Science, Engineering and Technology ",
publisher = "World Academy of Science, Engineering and Technology",
pages = "725--728",
booktitle = "ICCMSB 2015: International Conference on Computational and Molecular Systems Biology",
note = "International Conference on Computational and Molecular Systems Biology ; Conference date: 01-01-2015",
}