Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?

Marten Szibor, Christina Schenkl, Mario R.O. Barsottini, Luke Young, Anthony L. Moore

    Tutkimustuotos: Katsausartikkelivertaisarvioitu

    14 Lataukset (Pure)

    Abstrakti

    Some of the most threatening human diseases are due to a blockage of the mitochondrial electron transport chain (ETC). In a variety of plants, fungi, and prokaryotes, there is a naturally evolved mechanism for such threats to viability, namely a bypassing of the blocked portion of the ETC by alternative enzymes of the respiratory chain. One such enzyme is the alternative oxidase (AOX). When AOX is expressed, it enables its host to survive life-threatening conditions or, as in parasites, to evade host defenses. In vertebrates, this mechanism has been lost during evolution. However, we and others have shown that transfer of AOX into the genome of the fruit fly and mouse results in a catalytically engaged AOX. This implies that not only is the AOX a promising target for combating human or agricultural pathogens but also a novel approach to elucidate disease mechanisms or, in several cases, potentially a therapeutic cure for human diseases. In this review, we highlight the varying functions of AOX in their natural hosts and upon xenotopic expression, and discuss the resulting need to develop species-specific AOX inhibitors.

    AlkuperäiskieliEnglanti
    Sivut1337-1359
    Sivumäärä23
    JulkaisuBIOCHEMICAL JOURNAL
    Vuosikerta479
    Numero12
    DOI - pysyväislinkit
    TilaJulkaistu - kesäk. 2022
    OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

    Julkaisufoorumi-taso

    • Jufo-taso 1

    !!ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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