TY - JOUR
T1 - The Clinical Frailty Scale is a useful tool for predicting postoperative complications following elective colon cancer surgery at the age of 80 years and above
T2 - A prospective, multicentre observational study
AU - Niemeläinen, Susanna
AU - Huhtala, Heini
AU - Andersen, Jan
AU - Ehrlich, Anu
AU - Haukijärvi, Eija
AU - Koikkalainen, Suvi
AU - Koskensalo, Selja
AU - Kössi, Jyrki
AU - Mattila, Anne
AU - Pinta, Tarja
AU - Uotila-Nieminen, Mirjami
AU - Vihervaara, Hanna
AU - Hyöty, Marja
AU - Jämsen, Esa
N1 - Funding Information:
Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital partly supported this study financially. The Cancer Foundation Finland obtained external funding by awarding a grant, but they did not have any role in designing the study, collection, analysis or interpretation of the data or writing the manuscript.
Publisher Copyright:
© 2021 The Association of Coloproctology of Great Britain and Ireland
PY - 2021/5/15
Y1 - 2021/5/15
N2 - Aim: Identification of the risks of postoperative complications may be challenging in older patients with heterogeneous physical and cognitive status. The aim of this multicentre, observational study was to identify variables that affect the outcomes of colon cancer surgery and, especially, to find tools to quantify the risks related to surgery. Method: Patients aged ≥80 years with electively operated Stage I–III colon cancer were recruited. The prospectively collected data included comorbidities, results of the onco-geriatric screening tool (G8), Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI) and Mini Nutritional Assessment-Short Form (MNA-SF), and operative and postoperative outcomes. Results: A total of 161 patients (mean 84.5 years, range 80–97, 60% female) were included. History of cerebral stroke (64% vs. 37%, p = 0.02), albumin level 31–34 g/l compared with ≥35 g/l (57% vs. 32%, p = 0.007), CFS 3–4 and 5–9 compared with CFS 1–2 (49% and 47% vs. 16%, respectively) and American Society of Anesthesiologists score >3 (77% vs. 28%, P = 0.006) were related to a higher risk of complications. In multivariate logistic regression analysis CFS ≥3 (OR 6.06, 95% CI 1.88–19.5, p = 0.003) and albumin level 31–34 g/l (OR 3.88, 1.61–9.38, p = 0.003) were significantly associated with postoperative complications. Severe complications were more common in patients with chronic obstructive pulmonary disease (43% vs. 13%, p = 0.047), renal failure (25% vs. 12%, p = 0.021), albumin level 31–34 g/l (26% vs. 8%, p = 0.014) and CCI >6 (23% vs. 10%, p = 0.034). Conclusion: Surgery on physically and cognitively fit aged colon cancer patients with CFS 1–2 can lead to excellent operative outcomes similar to those of younger patients. The CFS could be a useful screening tool for predicting postoperative complications.
AB - Aim: Identification of the risks of postoperative complications may be challenging in older patients with heterogeneous physical and cognitive status. The aim of this multicentre, observational study was to identify variables that affect the outcomes of colon cancer surgery and, especially, to find tools to quantify the risks related to surgery. Method: Patients aged ≥80 years with electively operated Stage I–III colon cancer were recruited. The prospectively collected data included comorbidities, results of the onco-geriatric screening tool (G8), Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI) and Mini Nutritional Assessment-Short Form (MNA-SF), and operative and postoperative outcomes. Results: A total of 161 patients (mean 84.5 years, range 80–97, 60% female) were included. History of cerebral stroke (64% vs. 37%, p = 0.02), albumin level 31–34 g/l compared with ≥35 g/l (57% vs. 32%, p = 0.007), CFS 3–4 and 5–9 compared with CFS 1–2 (49% and 47% vs. 16%, respectively) and American Society of Anesthesiologists score >3 (77% vs. 28%, P = 0.006) were related to a higher risk of complications. In multivariate logistic regression analysis CFS ≥3 (OR 6.06, 95% CI 1.88–19.5, p = 0.003) and albumin level 31–34 g/l (OR 3.88, 1.61–9.38, p = 0.003) were significantly associated with postoperative complications. Severe complications were more common in patients with chronic obstructive pulmonary disease (43% vs. 13%, p = 0.047), renal failure (25% vs. 12%, p = 0.021), albumin level 31–34 g/l (26% vs. 8%, p = 0.014) and CCI >6 (23% vs. 10%, p = 0.034). Conclusion: Surgery on physically and cognitively fit aged colon cancer patients with CFS 1–2 can lead to excellent operative outcomes similar to those of younger patients. The CFS could be a useful screening tool for predicting postoperative complications.
KW - aged patients
KW - clinical frailty scale
KW - colon cancer
KW - postoperative outcome
KW - surgery
U2 - 10.1111/codi.15689
DO - 10.1111/codi.15689
M3 - Article
C2 - 33915013
AN - SCOPUS:85105826208
VL - 23
SP - 1824
EP - 1836
JO - COLORECTAL DISEASE
JF - COLORECTAL DISEASE
SN - 1462-8910
IS - 7
ER -
