TY - JOUR
T1 - The Movember Global Action Plan 1 (GAP1)
T2 - Unique Prostate Cancer Tissue Microarray Resource
AU - Ouellet, Véronique
AU - Erickson, Andrew
AU - Wiley, Kathy
AU - Morrissey, Colm
AU - Berge, Viktor
AU - Moreno, Carlos S.
AU - Tasken, Kristin Austlid
AU - Trudel, Dominique
AU - True, Lawrence D.
AU - Lewis, Michael S.
AU - Svindland, Aud
AU - Ertunc, Onur
AU - Vidal, Igor Damasceno
AU - Osunkoya, Adeboye O.
AU - Jones, Tracy
AU - Bova, G. Steven
AU - Lamminen, Tarja
AU - Achtman, Ariel H.
AU - Buzza, Mark
AU - Kouspou, Michelle M.
AU - Bigler, Steven A.
AU - Zhou, Xinchun
AU - Freedland, Stephen J.
AU - Mes-Masson, Anne Marie
AU - Garraway, Isla P.
AU - Trock, Bruce J.
AU - Taimen, Pekka
AU - Saad, Fred
AU - Mirtti, Tuomas
AU - Knudsen, Beatrice S.
AU - De Marzo, Angelo M.
N1 - Publisher Copyright:
©2022 The Authors; Published by the American Association for Cancer Research.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - BACKGROUND: The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project constructed a set of unique and richly annotated tissue microarrays (TMA) from prostate cancer samples obtained from multiple institutions across several global locations. METHODS: Three separate TMA sets were built that differ by purpose and disease state. RESULTS: The intended use of TMA1 (Primary Matched LN) is to validate biomarkers that help determine which clinically localized prostate cancers with associated lymph node metastasis have a high risk of progression to lethal castration-resistant metastatic disease, and to compare molecular properties of high-risk index lesions within the prostate to regional lymph node metastases resected at the time of prostatectomy. TMA2 (Pre vs. Post ADT) was designed to address questions regarding risk of castration-resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the castration-resistant phenotype. TMA3 (CRPC Met Heterogeneity)'s intended use is to assess the heterogeneity of molecular markers across different anatomic sites in lethal prostate cancer metastases. CONCLUSIONS: The GAP1-UTMA project has succeeded in combining a large set of tissue specimens from 501 patients with prostate cancer with rich clinical annotation. IMPACT: This resource is now available to the prostate cancer community as a tool for biomarker validation to address important unanswered clinical questions around disease progression and response to treatment.
AB - BACKGROUND: The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project constructed a set of unique and richly annotated tissue microarrays (TMA) from prostate cancer samples obtained from multiple institutions across several global locations. METHODS: Three separate TMA sets were built that differ by purpose and disease state. RESULTS: The intended use of TMA1 (Primary Matched LN) is to validate biomarkers that help determine which clinically localized prostate cancers with associated lymph node metastasis have a high risk of progression to lethal castration-resistant metastatic disease, and to compare molecular properties of high-risk index lesions within the prostate to regional lymph node metastases resected at the time of prostatectomy. TMA2 (Pre vs. Post ADT) was designed to address questions regarding risk of castration-resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the castration-resistant phenotype. TMA3 (CRPC Met Heterogeneity)'s intended use is to assess the heterogeneity of molecular markers across different anatomic sites in lethal prostate cancer metastases. CONCLUSIONS: The GAP1-UTMA project has succeeded in combining a large set of tissue specimens from 501 patients with prostate cancer with rich clinical annotation. IMPACT: This resource is now available to the prostate cancer community as a tool for biomarker validation to address important unanswered clinical questions around disease progression and response to treatment.
U2 - 10.1158/1055-9965.EPI-21-0600
DO - 10.1158/1055-9965.EPI-21-0600
M3 - Article
C2 - 35131885
AN - SCOPUS:85128161203
SN - 1055-9965
VL - 31
SP - 715
EP - 727
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 4
ER -
