The TAXINOMISIS Project: A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis

all partners of the TAXINOMISIS Consortium, Nathalie Timmerman, George Galyfos, Fragiska Sigala, Kalliopi Thanopoulou, Gert J de Borst, Lazar Davidovic, Hans-Henning Eckstein, Nenad Filipovic, Roberto Grugni, Michael Kallmayer, Dominique P V de Kleijn, Igor Koncar, Michalis D Mantzaris, Elisabeth Marchal, Miltiadis Matsagkas, Perica Mutavdzic, Domenico Palombo, Gerard Pasterkamp, Vassiliki T PotsikaEvangelos Andreakos, Dimitrios I Fotiadis, Terho Lehtimäki, Pashupati Mishra, Emma Raitoharju, Nina Mononen

Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

6 Sitaatiot (Scopus)
12 Lataukset (Pure)

Abstrakti

INTRODUCTION: Asymptomatic carotid artery stenosis (ACAS) may cause future stroke and therefore patients with ACAS require best medical treatment. Patients at high risk for stroke may opt for additional revascularization (either surgery or stenting) but the future stroke risk should outweigh the risk for peri/post-operative stroke/death. Current risk stratification for patients with ACAS is largely based on outdated randomized-controlled trials that lack the integration of improved medical therapies and risk factor control. Furthermore, recent circulating and imaging biomarkers for stroke have never been included in a risk stratification model. The TAXINOMISIS Project aims to develop a new risk stratification model for cerebrovascular complications in patients with ACAS and this will be tested through a prospective observational multicentre clinical trial performed in six major European vascular surgery centres.

METHODS AND ANALYSIS: The risk stratification model will compromise clinical, circulating, plaque and imaging biomarkers. The prospective multicentre observational study will include 300 patients with 50%-99% ACAS. The primary endpoint is the three-year incidence of cerebrovascular complications. Biomarkers will be retrieved from plasma samples, brain MRI, carotid MRA and duplex ultrasound. The TAXINOMISIS Project will serve as a platform for the development of new computer tools that assess plaque progression based on radiology images and a lab-on-chip with genetic variants that could predict medication response in individual patients.

CONCLUSION: Results from the TAXINOMISIS study could potentially improve future risk stratification in patients with ACAS to assist personalized evidence-based treatment decision-making.

AlkuperäiskieliEnglanti
Sivute13411
JulkaisuEuropean Journal of Clinical Investigation
Vuosikerta50
Numero12
DOI - pysyväislinkit
TilaJulkaistu - 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 1

Sormenjälki

Sukella tutkimusaiheisiin 'The TAXINOMISIS Project: A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä