The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

Aysel Ahadova, Toni T. Seppälä, Christoph Engel, Richard Gallon, John Burn, Elke Holinski-Feder, Verena Steinke-Lange, Gabriela Möslein, Maartje Nielsen, Sanne W. ten Broeke, Luigi Laghi, Mev Dominguez-Valentin, Gabriel Capella, Finlay Macrae, Rodney Scott, Robert Hüneburg, Jacob Nattermann, Michael Hoffmeister, Hermann Brenner, Hendrik BläkerMagnus von Knebel Doeberitz, Julian R. Sampson, Hans Vasen, Jukka Pekka Mecklin, Pål Møller, Matthias Kloor

Tutkimustuotos: Katsausartikkelivertaisarvioitu

57 Sitaatiot (Scopus)

Abstrakti

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.

AlkuperäiskieliEnglanti
Sivut800-811
Sivumäärä12
JulkaisuInternational journal of cancer
Vuosikerta148
Numero4
DOI - pysyväislinkit
TilaJulkaistu - 15 helmik. 2021
Julkaistu ulkoisestiKyllä
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

!!ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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