Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices

Penny Nymark, Martine Bakker, Susan Dekkers, Remy Franken, Wouter Fransman, Amaia García-Bilbao, Dario Greco, Mary Gulumian, Niels Hadrup, Sabina Halappanavar, Vesa Hongisto, Karin Sørig Hougaard, Keld Alstrup Jensen, Pekka Kohonen, Antti Joonas Koivisto, Miikka Dal Maso, Thies Oosterwijk, Mikko Poikkimäki, Isabel Rodriguez-Llopis, Rob StierumJorid Birkelund Sørli, Roland Grafström

Tutkimustuotos: Katsausartikkelivertaisarvioitu

45 Sitaatiot (Scopus)
52 Lataukset (Pure)

Abstrakti

Advanced material development, including at the nanoscale, comprises costly and complex challenges coupled to ensuring human and environmental safety. Governmental agencies regulating safety have announced interest toward acceptance of safety data generated under the collective term New Approach Methodologies (NAMs), as such technologies/approaches offer marked potential to progress the integration of safety testing measures during innovation from idea to product launch of nanomaterials. Divided in overall eight main categories, searchable databases for grouping and read across purposes, exposure assessment and modeling, in silico modeling of physicochemical structure and hazard data, in vitro high-throughput and high-content screening assays, dose-response assessments and modeling, analyses of biological processes and toxicity pathways, kinetics and dose extrapolation, consideration of relevant exposure levels and biomarker endpoints typify such useful NAMs. Their application generally agrees with articulated stakeholder needs for improvement of safety testing procedures. They further fit for inclusion and add value in nanomaterials risk assessment tools. Overall 37 of 50 evaluated NAMs and tiered workflows applying NAMs are recommended for considering safer-by-design innovation, including guidance to the selection of specific NAMs in the eight categories. An innovation funnel enriched with safety methods is ultimately proposed under the central aim of promoting rigorous nanomaterials innovation.

AlkuperäiskieliEnglanti
Artikkeli1904749
Sivumäärä13
JulkaisuSmall
Vuosikerta16
Numero6
DOI - pysyväislinkit
TilaJulkaistu - 2020
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tutkimusalat

  • Stage-Gate innovation funnel
  • human risk assessment tools
  • nanomaterials
  • new approach methodologies
  • safer by design

Julkaisufoorumi-taso

  • Jufo-taso 2

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