Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice André, Carsten DenkertMartine Piccart, Elvire Roblin, Stefan Michiels

Tutkimustuotos: ArticleScientificvertaisarvioitu

1 Lataukset (Pure)

Abstrakti

The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.

AlkuperäiskieliEnglanti
Artikkeli3
JulkaisuNPJ breast cancer
Vuosikerta8
DOI - pysyväislinkit
TilaJulkaistu - 11 tammik. 2022
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

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